Chemical refrigerants, which transfer heat in cooling systems, such as air conditioners, must balance four key factors: efficiency, greenhouse gas mitigation, flammability and toxicity.
These factors inextricably work together; increasing one of them necessarily means effecting another. For example, to create a more efficient refrigerant, you must either make it flammable or contribute to global warming. The best chemical refrigerant is the one that optimizes the balance of these four factors—and the best refrigerant at this time is R-32.